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KMID : 0370920070240010085
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Yeungnam Univercity Journal of Medicine
2007 Volume.24 No. 1 p.85 ~ p.90
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Acute Myeloid Leukemia with t(8;21)(q22;q22) (AML1/ETO) in a Patient with Marked Hypocellularity and Low Blasts Count
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Chun Sung-Ho
Cho Hee-Soon
Lee Chae-Hoon
Kim Kyung-Dong
Kim Min-Kyoung
Hyun Myung-Soo
Jung Soon-Il
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Abstract
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According to the World Health Organization (WHO) classification system, cases with t(8;21)(q22;q22) should be diagnosed as acute myeloid leukemia (AML) even with a blast count of less than 20 percent in blood or bone marrow. It is an uncommon manifestation, moreover hypocellularity is rarely observed in this subtype of leukemia. Here, we report a case of t(8;21) in a patient with marked hypocellularity of less than 5 percent and a blast count of less than 20 percent. This patient responded relatively well to chemotherapy. An allogeneic bone marrow transplantation was performed with good engraftment . This case suggests that hypocellular AML with a t(8;21) has as good a prognosis as hypercellular AML with t(8;21).
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KEYWORD
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Acure myeloid leukemia, t(8, 21)(q22, q22), Hypocellularity
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